After the collapse of the Soviet Union, Margarita Breitkreiz came to Germany with her parents and brother in 1994. In 2006 she completed her acting studies at the Ernst Busch Academy of Dramatic Arts in Berlin, where she also lives.
At Berlin's Volksbühne, she appeared in Frank Castorf's productions of Der Idiot (The Idiot, 2003/2004), Medea (2009/2010), Die Soldaten, Nach Moskau nach Moskau, Der Kaufmann von Berlin(The Soldiers, To Moscow to Moscow, The Merchant of Berlin, 2010/2011), Der Spieler (The Gambler, 2011/2012), Der Geizige (The Miser, 2013), and Die Brüder Karamasow (The Brothers Karamazov) and Ein schwaches Herz (A Weak Heart) in 2017. She also appeared in Martin Wuttke's production of Podpolje (2004).
In 2004 she starred with Axel Prahl in Hartmut Schoen's hit TV film Der Grenzer und das Mädchen (The Border Guard and the Girl).
In addition to lead roles in episodes of the Rosenheim Cops, Polizeiruf 110, RTL crime series Abschnitt 40 and Tatort episodes “Unsterblich” and “Das Mädchen in Galina” (“Immortal” and “The Girl in Galina”), her roles in short films should also be noted, in e.g. Weggang (Departure, 2004, director: Clemens von Wedemeyer) and Russische Frauen tragen gerne kurze Röcke (Russian Women Like to Wear Short Skirts). In Michael Koch's 2016 film Marija, she played the title role.