Valerie Oberhof studied acting at the Berlin University of the Arts from 1997 to 2001. She subsequently held various engagements at the Deutsches Theater Göttingen, the Stuttgart State Opera and the Meininger Theater. Since 2006 she has been working as a freelance actress. In Berlin, she works at the Hebbel Theater, the Sophiensaelen and the Deutsches Theater Berlin.
In 2018 Oberhof founded the German-language rock band »Bonnie und die Scotts« with Ulf Steinhauer aka Django Boogiebastard Silbermann (Los Banditos). Since 2018 frontwoman of the same formation. Oberhof lives in Berlin. In February 2021 she was one of the signatories of the manifesto #ActOut.